Dosing and administration

TYVERB is an oral medication, taken once per day, every day

Tyverb is an oral treatment that is presented as a 250 mg, yellow, oval tablet with the letters ‘GS XJG’ debossed on one side.

It is important that patients are given the correct pack for their indication, so that they take the correct dosage.

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Tyverb in combination with capecitabine

Tyverb and capecitabine are dispensed in separate packs.

  • Tyverb is available in 105-tablet bottles, which cover a 3-week supply*
  • Capecitabine tablets are available in two strengths: 150 mg and 500 mg

In the treatment of HER2+ metastatic breast cancer, the recommended dosage of Tyverb, when used in combination with capecitabine, is 1250 mg (five 250 mg tablets) taken once a day, continuously.1

When taken in combination with Tyverb, capecitabine should be given at a dose of 2000 mg/m2 per day, taken in two divided doses 12 hours apart (morning and evening), for the first 14 days of each 21-day treatment cycle.1

Capecitabine should be taken with food or within 30 minutes of eating a meal.1,2

Tyverb 1250 mg daily dose chart

Further information on dosing and administration can be found in the Tyverb Summary of Product Characteristics.1

*Blister packs are available in some countries within Asia.

Tyverb in combination with capecitabine: clinical evidence

Reference: 1. Tyverb® (lapatinib) Summary of Product Characteristics. Camberley, UK: Novartis Europharm Limited; 11 August 2015. 2. Xeloda (capecitabine) Summary of Product Characteristics. Hertfordshire, UK: Roche Registration Limited; 26 July 2016.